Peptides hormones play an important role in the regulation of manifold activities in the body. Many of them transmit their activity through G protein-coupled receptors (GPCR), which are among the most promising drug targets nowadays. The neuropeptide Y hormone family contains three members that bind in human to four different so-called Y-receptors. All play an important role in the regulation of food-intake. By a combination of X-ray analysis, NMR, molecular modelling and crosslinking combined with mass spectrometry, we have recently identified the distinct binding modes of NPY peptides to their Y-receptors. This now allows for the identification of signals and its application for novel drug concepts.
Annette G. Beck-Sickinger studied at the University of Tübingen (Germany) and worked at Scripps Research Institute, La Jolla, University of Copenhagen and the ETH Zürich. Since 1999, she is full professor of Biochemistry at Leipzig University. Her major research fields include peptide hormones, G protein-coupled receptors and protein modification to study function and interaction. Bioorganic synthesis, molecular biology and cell biochemistry are tightly connected. Furthermore, the identification of novel targets, novel therapeutic concepts and innovative approaches for biomaterials are focussed. She has been awarded with many prices including the Leonidas Zervas Award (EPS), the Albrecht Kossel Award of Biochemistry of the GDCh (2018) and the Du Vigneaud Award of the American Peptide Society (2019). She is member of the Saxonian Academy of Science, the Göttinger Academy of Science and of the Leopoldina. In 2017, she was awarded with the Saxonian Order of Merit.
Moderation: Professorin Dr. Sabine Müller
-------
Organizational information on the digital lecture
The Alfried Krupp Wissenschaftskolleg is offering this event live as a zoom meeting, in which viewers can also take part in the subsequent discussion with video contributions.
- We would be delighted if you gave your real name when dialing into Zoom. Of course, you can also take part in the event under a pseudonym.
- A list of all participants is available to all those involved during the entire event.
- During the lecture, the microphones of the audience are all automatically muted so as not to generate any disturbing background noise. You can turn on the audience's camera during the lecture.
- In the discussion that follows, requests to speak or questions can be displayed using the "Raise hand" function. You can find these - depending on the device - under the button "Participant", "More" or "Reactions" in Zoom. You can also lower your hand again if you want to withdraw the question.
- The moderator keeps a speech list and gives the floor in the order of the messages. If the moderator asks you to bring your question or request to speak, the user interface will ask you to turn on your microphone. If you have not already done so, you are welcome to turn on your camera. This is particularly desirable when presenting longer requests to speak so that the presenter can also see who is asking the question or who is making the comment.
- Of course, you also have the option of asking your questions in writing in the chat.
Recording of the digital lecture
The digital lecture will be recorded so that it can be used in the college's media library. Only the speaker, his / her presentation and the moderator can be heard or seen in the recording. Video, audio or chat contributions are not recorded. A “REC” symbol at the edge of the screen informs the participants about the current recording.