Combinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma serine protease that initiates the contact system. This system starts a cascade of procoagulant and proinflammatory reactions via the intrinsic pathway of coagulation, and the bradykinin producing kallikrein-kinin system, respectively. The biochemistry of the contact system in vitro is well understood, however its in vivo functions are just beginning to emerge. This presentation will summarize roles of the FXII-driven contact system in vivo.
Professor Dr. Thomas Renné studied medicine and chemistry at the University of Mainz. After a research fellowship for bioorganic chemistry at the Kyoto University/Japan, he did his PhD thesis and his MD thesis at the University of Mainz. 2007, he got his docent degree in Clinical Biochemistry at the University of Würzburg. He qualified as a Specialist in Clinical Chemistry/Laboratory Medicine 2008. From 2008 to 2013 he was a full Professor of Clinical Chemistry and Coagulation at the Karolinska Institute and University Hospital, Stockholm/ Sweden. Since 2013 he is a full Professor of Clinical Chemistry and Director of the Institute at the University Medical Center Hamburg-Eppendorf.
Moderation: Professor Dr. Sven Hammerschmidt