Recent data show that histone deacetylase (HDAC) and histone acetyltransferase (HAT) regulate chromatin accessibility and the functions of many proteins by controlling acetylation of key lysines. Use of HDAC inhibitors promotes acetylation and typically promotes gene transcription and cell functions, whereas use of HAT inhibitors decreases acetylation and decreases gene transcription and cell activation. This talk will discuss our ongoing studies analyzing use of HDAC and HAT inhibitors to control Foxp3+ T regulatory cell functions in inflammation and immune responses.
Wayne W. Hancock is Professor of Pathology and Laboratory Medicine at the University of Pennsylvania, Philadelphia, which became the first medical school to establish a separate degree-granting Ph.D. program in Immunology. His research focusses on Transplant immunobiology, inflammation and mechanisms of disease. In 1989 Professor Hancock was Fellow at the Royal College of Pathologists of Australasia.
Moderation: Professor Dr. Barbara M. Bröker